Description

R-Cinex 450 (Isoniazid/Rifampicin) – Effective Combination Therapy for Tuberculosis (TB)

R-Cinex 450 is a prescription antitubercular medicine formulated with Isoniazid and Rifampicin, two first-line antibiotics widely used in combination for the treatment of active tuberculosis (TB) caused by Mycobacterium tuberculosis. The combination works by targeting TB bacteria through different mechanisms, helping stop bacterial growth, eliminate infection, and reduce the risk of drug resistance when taken as part of a complete treatment regimen. The medicine should only be used under medical supervision, as the appropriate dosage depends on the patient’s body weight, treatment phase, and overall health condition.

R-Cinex 450 is commonly prescribed for the treatment of pulmonary and extrapulmonary tuberculosis as part of combination antitubercular therapy. It is generally used according to national and international TB treatment guidelines. Because treatment requirements vary from one patient to another, this medicine should never be used without the advice of a qualified healthcare professional.

• Key Features

1. Contains Isoniazid and Rifampicin in a fixed-dose combination
2. Prescription-only antitubercular medication
3. Oral tablet for convenient once-daily administration
4. Effective for the treatment of active tuberculosis (TB)
5. Helps reduce the risk of developing drug-resistant TB when taken as prescribed
6. Manufactured under quality pharmaceutical standards

How to Take R-Cinex 450

For the best therapeutic effect, take the tablet exactly as directed by your healthcare provider. It is generally recommended to swallow the tablet whole with a glass of water on an empty stomach, preferably 1 hour before or 2 hours after meals, unless instructed otherwise. Do not crush, chew, or split the tablet unless advised by your doctor. Avoid missing doses and complete the full course of treatment to ensure successful therapy and minimize the risk of relapse or antibiotic resistance.

• General Dosage Reference

Medical Condition	Recommended Adult Dose
Active Pulmonary Tuberculosis	As prescribed according to body weight and TB treatment guidelines
Extrapulmonary Tuberculosis	As directed by the treating physician
Continuation Phase of TB Therapy	Dose determined by physician
Combination TB Treatment	Used with other antitubercular medicines as prescribed

The exact dosage should always be determined by your healthcare provider based on body weight, treatment regimen, and clinical response.

Safety Information

Before starting R-Cinex 450, tell your healthcare provider if you have liver disease, kidney disease, hepatitis, HIV infection, diabetes, seizure disorders, or any known allergy to isoniazid or rifampicin. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their doctor before taking this medicine. Inform your healthcare provider about all prescription medicines, over-the-counter drugs, vitamins, and herbal supplements, as rifampicin may interact with several medications, including oral contraceptives, anticoagulants, antifungal medicines, and certain antiviral drugs.

Most people tolerate R-Cinex 450 well when taken as prescribed. However, some individuals may experience mild side effects such as nausea, vomiting, stomach discomfort, headache, fatigue, loss of appetite, or orange-red discoloration of urine, tears, saliva, and sweat. Seek immediate medical attention if you develop severe allergic reactions, yellowing of the skin or eyes, persistent vomiting, severe abdominal pain, vision problems, numbness or tingling in the hands or feet, or symptoms suggestive of liver injury.

Product Specifications

Specification	Information
Brand	R-Cinex 450
Generic Name	Isoniazid/Rifampicin
Active Ingredients	Isoniazid + Rifampicin
Strength	450 mg Combination Tablet
Dosage Form	Oral Tablet
Drug Class	Antitubercular Combination Antibiotic
Route of Administration	Oral
Prescription Status	Prescription Required
Storage	Store below 25°C in a cool, dry place away from moisture and direct sunlight

Frequently Asked Questions

Can R-Cinex 450 be taken with food?

It is generally recommended to take the tablet on an empty stomach unless your healthcare provider advises otherwise.

How long should I take R-Cinex 450?

Tuberculosis treatment usually continues for several months. Always complete the full course prescribed by your healthcare provider.

Why does R-Cinex 450 cause orange-colored urine?

Rifampicin may cause harmless orange-red discoloration of urine, tears, saliva, and sweat. This is a normal and expected effect of the medicine.

Is R-Cinex 450 an antibiotic?

Yes. It contains two antibiotics—isoniazid and rifampicin—that are specifically used to treat tuberculosis and should only be used as prescribed.

What should I do if I miss a dose?

Take the missed dose as soon as you remember if appropriate for your treatment schedule. Do not take two doses together. Consult your healthcare provider if you are unsure.